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ORIGINAL ARTICLE
Year : 2018  |  Volume : 111  |  Issue : 4  |  Page : 127-131

Comparative study of specular microscopy in type І diabetes with and without diabetic retinopathy compared with normal persons


1 Department of Opthalmolgy, Marg One Day Surgery Hospital, Ain Shams University, Cairo, Egypt
2 Department of Opthalmolgy, Ain Shams University, Cairo, Egypt

Correspondence Address:
Mohamed H.A Mohamed
1 Mousa st. from Portsaid st.,Mit Ghamr, Postal code 35612
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejos.ejos_43_18

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Purpose This study compared corneal endothelial changes in morphology and corneal thickness by specular microscopy in two groups of type I diabetes with and without diabetic retinopathy and were compared with a normal control. Patients and methods The study included 45 participants aged 19–29 years as follow: 15 eyes of 15 patients with type I diabetes without retinopathy (group I), 15 eyes of 15 patients with type I diabetes with retinopathy (group II), and 15 eyes of 15 normal persons matched for age and sex with the case groups (group III). Noncontact specular microscope (CEM-530; NIDEK) was used to assess the corneal endothelium for endothelial density, coefficient of variation in cell size, percentage of hexagonal cells, and central thickness of the cornea. Results There was a highly significant decrease in endothelial density (P=0.002) and hexagonal cell percentage (P=0.001) in diabetics compared with normal control. A highly significant increased variation in cell size (P=0.001) and corneal thickness (P=0.001) was reported in diabetics rather than control. Diabetic retinopathy tends to have no effect on corneal endothelial morphology such as endothelial density, variation in cell size, percentage of hexagonal cells, and corneal thickness. Conclusion Type I diabetes mellitus was found to affect corneal endothelial morphology such as decreased endothelial cell density and hexagonal cell percentage and increased cell size variability impairing the endothelial function leading to increased central corneal thickness.


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