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ORIGINAL ARTICLE
Year : 2013  |  Volume : 106  |  Issue : 3  |  Page : 129-133

Intravitreal bevacizumab (Avastin) with peripheral retinal cryotherapy for patients with posterior retinopathy of prematurity and vitreous hemorrhage


Department of Ophthalmology, Ain Shams University, Cairo, Egypt

Correspondence Address:
Mohammad M. K. Diab
Hospital Aseer Region, Khamesmashat City King Saudi Arabia

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2090-0686.127351

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Purpose To report the short-term anatomic response of intravitreal bevacizumab (Avastin) and peripheral cryotherapy for the treatment of posterior retinopathy of prematurity (ROP) with vitreous hemorrhage in a small series of patients. Patients and methods This was a retrospective study that included 19 eyes of 14 premature babies with posterior ROP and vitreous hemorrhage in whom conventional laser treatment could not be applied. Patients received an intravitreal injection of bevacizumab (Avastin) together with peripheral retinal cryotherapy. Results Vascularization began to regress within a few days after the injection, but vitreous hemorrhage absorbed more slowly. Repeat intravitreal injections of bevacizumab were administered in eight eyes within 1 month from the first injection. There were varying development of tractional retinal detachments in two of the eyes, but the ROP component quieted in all cases. Conclusion Off-label use of intravitreal bevacizumab with peripheral retinal cryotherapy appears to be useful as a treatment for posterior ROP when laser treatment is precluded. It improves dilatation, regressing and quiescent the disease, and improves visibility.


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